Late complications of immune deviation therapy in a nonhuman primate.

نویسندگان

  • C P Genain
  • K Abel
  • N Belmar
  • F Villinger
  • D P Rosenberg
  • C Linington
  • C S Raine
  • S L Hauser
چکیده

The administration of antigens in soluble form can induce antigen-specific immune tolerance and suppress experimental autoimmune diseases. In a marmoset model of multiple sclerosis induced by myelin oligodendrocyte glycoprotein (MOG), marmosets tolerized to MOG were protected against acute disease, but after tolerization treatment a lethal demyelinating disorder emerged. In these animals, MOG-specific T cell proliferative responses were transiently suppressed, cytokine production was shifted from a T helper type 1 (TH1) to a TH2 pattern, and titers of autoantibodies to MOG were enhanced. Thus, immune deviation can increase concentrations of pathogenic autoantibodies and in some circumstances exacerbate autoimmune disease.

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عنوان ژورنال:
  • Science

دوره 274 5295  شماره 

صفحات  -

تاریخ انتشار 1996